Depression doesn't have to be your permanent address.
When standard treatments haven't worked, ketamine therapy offers a new path forward. At Ketamine of Philadelphia, we combine cutting-edge medicine with genuine human warmth — because healing should feel like coming home.
A Different Kind of Clinic —
One That Actually Feels Like Care
We know what it's like to feel like you've tried everything. The medications that didn't work. The therapists who couldn't quite reach you. The heavy, exhausting sense that there's no way out.
Ketamine of Philadelphia was founded on a simple conviction: that people deserve a treatment experience that treats them like human beings first. Our protocol is rigorous, evidence-based, and administered by licensed medical professionals. But the way we show up for you? That's just genuinely good.
Located in the heart of Philadelphia on Pennsylvania Avenue, our clinic is a soft place to land — literally and figuratively. Warm tones, comfortable seating, and a team that remembers your name. This is healthcare that doesn't feel clinical.
Treatment Options Designed
for Real People
Every journey is different. We offer multiple pathways to help you find the one that fits.
IV Ketamine Infusion Therapy
The gold standard in ketamine treatment. Delivered intravenously under medical supervision, our infusion protocol allows precise dosing and rapid onset — typically within 20 to 40 minutes. Sessions take approximately 40 minutes in our comfortable treatment rooms.
- Medically supervised throughout
- Precise, individualized dosing
- Comfortable reclining chairs
- Pre- and post-session monitoring
Ketamine-Assisted Psychotherapy
The powerful combination of ketamine's neuroplastic effects paired with guided therapy. This integrative approach helps you process deep emotions and build lasting psychological change during the heightened states of receptivity that ketamine creates.
- Integrated with licensed therapists
- Focus on deep emotional processing
- Builds lasting behavioral change
- Preparation and integration sessions included
Spravato (Esketamine) Treatment
FDA-approved nasal spray ketamine for treatment-resistant depression. Administered in-clinic with twice-weekly monitoring, Spravato offers a convenient alternative to IV infusion with a well-established safety profile and insurance coverage options.
- FDA-approved for TRD
- Nasal spray — no needle required
- Structured REMS program
- Insurance coverage available
Nerve Block Injections
Targeted injections for chronic pain management, including occipital nerve blocks, trigeminal nerve blocks, and other peripheral nerve injections. These procedures can provide significant relief for conditions like migraines, facial pain, and neuropathic pain.
- Targeted pain relief
- Minimally invasive procedure
- Outpatient setting
- Comprehensive pain assessment
Conditions We Help You Move Through
Your Path to Relief,
Step by Step
We've simplified the journey so you can focus on what matters — getting better.
Initial Consultation
We start with a thorough, no-pressure conversation. Tell us your story. We'll review your medical history, discuss your symptoms, and determine if ketamine therapy is the right fit for you. No judgment. No rush.
Medical Evaluation
Our licensed provider conducts a comprehensive assessment — including vitals, psychiatric history, and any necessary lab work — to ensure ketamine therapy is safe for you personally.
Your Treatment Plan
Together, we design a personalized protocol — choosing the right modality, dosage, and session frequency. You'll know exactly what to expect before your first treatment.
Treatment & Support
Each session takes place in our warm, comfortable clinic. You'll be monitored the entire time. Afterward, we'll check in with you and adjust your plan as needed. You're never alone in this.
After years of trying different medications and therapies, I felt like I'd hit a wall. The team at Ketamine of Philadelphia didn't just prescribe treatment — they listened. They made me feel safe, heard, and genuinely cared for. For the first time in a long time, I woke up and didn't dread the day ahead.
Everything You Need to Know
Starting ketamine therapy is a big decision. We want you to feel informed and confident.
Ketamine is a medication that has been used safely for decades in emergency rooms and surgical settings. At low, controlled doses, it works on glutamate receptors in the brain to promote neural connectivity and rapid relief from depression and anxiety symptoms. Unlike traditional antidepressants that can take weeks to work, ketamine therapy often produces noticeable improvement within hours to days.
When administered by licensed medical professionals in a controlled clinical setting, ketamine therapy is considered safe. We conduct thorough medical screenings before starting treatment, monitor your vitals throughout each session, and adjust dosages based on your individual response. Common side effects are mild and temporary — things like slight dizziness or nausea during the session.
Most people describe the experience as calm and introspective. You'll recline in a comfortable chair, put on headphones with calming music, and the medication will begin working within minutes. Some people feel a sense of detachment or mild dissociation — it's like floating. Others simply feel a profound sense of peace. The session lasts about 40 minutes, and you'll rest in our clinic for a bit afterward before going home.
Every person's journey is different. Many patients begin to notice improvement after just 2 to 4 sessions, though a full induction course typically involves 6 to 8 sessions over a few weeks. After that, we'll discuss a maintenance plan tailored to your needs. Some people need periodic boosters; others achieve lasting relief and don't need ongoing treatments.
We accept many major insurance plans, and our team can help you verify your coverage during the consultation. For Spravato (esketamine) treatment, insurance coverage is more commonly available. For IV ketamine infusion therapy, we provide superbills that you can submit to your insurance for possible out-of-network reimbursement. We'll always be transparent about costs upfront — no surprises.
For safety, we strongly recommend that you have someone drive you home after your session, or arrange for a ride service. The effects of ketamine can linger for a short time, and we want to make sure you get home safely. We'll give you clear post-session instructions and allow time for observation before you leave the clinic.
You Don't Have to Keep Carrying This Alone.
Taking the first step is often the hardest part. But you've already done it — you're here, looking for answers. That takes courage. Let us meet you where you are.
We're Here When You're Ready
Whether you have questions, want to schedule a consultation, or just need someone to talk to — we're here. Reach out in whatever way feels most comfortable for you.
Philadelphia, PA 19130-3000
Sat – Sun: By Appointment
